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Page 1
Orphan nuclear receptor NR4A1 regulates transforming growth factor-beta signaling and fibrosis.
Palumbo-Zerr K, Zerr P, Distler A, Fliehr J, Mancuso R, Huang J, Mielenz D, Tomcik M, Fürnrohr BG, Scholtysek C, Dees C, Beyer C, Krönke G, Metzger D, Distler O, Schett G, Distler JH. Palumbo-Zerr K, et al. Nat Med. 2015 Feb;21(2):150-8. doi: 10.1038/nm.3777. Epub 2015 Jan 12. Nat Med. 2015. PMID: 25581517
Small-molecule NR4A1 agonists can overcome this lack of active NR4A1 and inhibit experimentally-induced skin, lung, liver, and kidney fibrosis in mice. Our data demonstrate a regulatory role of NR4A1 in TGF-beta signaling and fibrosis, providing the fi …
Small-molecule NR4A1 agonists can overcome this lack of active NR4A1 and inhibit experimentally-induced skin, lung, liv …
A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection.
Tang X, Xue D, Zhang T, Nilsson-Payant BE, Carrau L, Duan X, Gordillo M, Tan AY, Qiu Y, Xiang J, Schwartz RE, tenOever BR, Evans T, Chen S. Tang X, et al. Nat Cell Biol. 2023 Mar;25(3):381-389. doi: 10.1038/s41556-023-01095-y. Epub 2023 Mar 13. Nat Cell Biol. 2023. PMID: 36918693 Free PMC article.
Lung airway organoids, lung alveolar organoids and cardiomyocytes derived from isogenic CIART(-/-) human pluripotent stem cells were significantly resistant to SARS-CoV-2 infection, independently of viral entry. Single-cell RNA-sequencing analysis further validated …
Lung airway organoids, lung alveolar organoids and cardiomyocytes derived from isogenic CIART(-/-) human pluripotent stem cell …
Key Functions and Therapeutic Prospects of Nur77 in Inflammation Related Lung Diseases.
Banno A, Lakshmi SP, Reddy AT, Kim SC, Reddy RC. Banno A, et al. Am J Pathol. 2019 Mar;189(3):482-491. doi: 10.1016/j.ajpath.2018.10.002. Epub 2018 Nov 7. Am J Pathol. 2019. PMID: 30414411 Free PMC article. Review.
This review addresses the mechanisms that control Nur77 as well as its known roles in inflammation-related lung diseases. Evidence regarding the therapeutic potential of Nur77-targeting molecules will also be presented. Although current knowledge is limited, additio …
This review addresses the mechanisms that control Nur77 as well as its known roles in inflammation-related lung diseases. Evid …
Nr4a1 marks a distinctive ILC2 activation subset in the mouse inflammatory lung.
Xu S, Zhang Y, Liu X, Liu H, Zou X, Zhang L, Wang J, Zhang Z, Xu X, Li M, Li K, Shi S, Zhang Y, Miao Z, Zha J, Yu Y. Xu S, et al. BMC Biol. 2023 Oct 13;21(1):218. doi: 10.1186/s12915-023-01690-3. BMC Biol. 2023. PMID: 37833706 Free PMC article.
Furthermore, we demonstrate that the Nr4a1(+)ILC2s are restrained from activating by the programmed cell death protein-1 (PD-1), which negatively modulates their activation-related regulons. PD-1 deficiency places the non-activation ILC2s in a state that is prone to activa …
Furthermore, we demonstrate that the Nr4a1(+)ILC2s are restrained from activating by the programmed cell death protein-1 (PD-1), whic …
TGFbeta-Induced Lung Cancer Cell Migration Is NR4A1-Dependent.
Hedrick E, Mohankumar K, Safe S. Hedrick E, et al. Mol Cancer Res. 2018 Dec;16(12):1991-2002. doi: 10.1158/1541-7786.MCR-18-0366. Epub 2018 Aug 2. Mol Cancer Res. 2018. PMID: 30072581 Free PMC article.
Thus, NR4A1 also plays an integral role in mediating TGFbeta-induced lung cancer invasion, and the NR4A1 ligand CDIM8, which binds nuclear NR4A1, represents a novel therapeutic approach for TGFbeta-induced blocking of lung cancer migration/invas …
Thus, NR4A1 also plays an integral role in mediating TGFbeta-induced lung cancer invasion, and the NR4A1 ligand CDIM8, …
RESVERATROL BINDS NUCLEAR RECEPTOR 4A1 (NR4A1) AND ACTS AS AN NR4A1 ANTAGONIST IN LUNG CANCER CELLS.
Zhang L, Martin G, Mohankumar K, Hampton JT, Liu WR, Safe S. Zhang L, et al. Mol Pharmacol. 2022 Jun 9;102(2):80-91. doi: 10.1124/molpharm.121.000481. Online ahead of print. Mol Pharmacol. 2022. PMID: 35680166 Free PMC article.
Resveratrol also inhibited NR4A1-dependent transactivation in H460 and H1299 lung cancer cells suggesting that resveratrol is an NR4A1 antagonist. ...Significance Statement We have examined the mechanism of action of resveratrol and show binding to NR4A1 …
Resveratrol also inhibited NR4A1-dependent transactivation in H460 and H1299 lung cancer cells suggesting that resveratrol is …
NR4A1 Promotes LPS-Induced Acute Lung Injury through Inhibition of Opa1-Mediated Mitochondrial Fusion and Activation of PGAM5-Related Necroptosis.
Zhu P, Wang J, Du W, Ren J, Zhang Y, Xie F, Xu G. Zhu P, et al. Oxid Med Cell Longev. 2022 Feb 18;2022:6638244. doi: 10.1155/2022/6638244. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35222801 Free PMC article.
In this study, we employed NR4A1(-/-) mice to decipher the role of NR4A1 in the onset and progression of acute lung injury with a focus on mitochondrial damage and necroptosis. ...Knockout of NR4A1 overtly improved lung tissue morphology, inhibi …
In this study, we employed NR4A1(-/-) mice to decipher the role of NR4A1 in the onset and progression of acute lung inj …
Deficiency of the Transcription Factor NR4A1 Enhances Bacterial Clearance and Prevents Lung Injury During Escherichia Coli Pneumonia.
Cui P, Wu S, Xu X, Ye H, Hou J, Liu X, Wang H, Fang X. Cui P, et al. Shock. 2019 Jun;51(6):787-794. doi: 10.1097/SHK.0000000000001184. Shock. 2019. PMID: 29846361
WT and Nr4a1 mice were subjected to E. coli or sham pneumonia. Bacterial load, lung injury severity, inflammatory cell infiltration, and cytokines were assessed at 0, 4, and 18 h after surgery. ...The survival advantage of Nr4a1 mice was associated with decre …
WT and Nr4a1 mice were subjected to E. coli or sham pneumonia. Bacterial load, lung injury severity, inflammatory cell infiltr …
Pterostilbene pre-treatment reduces LPS-induced acute lung injury through activating NR4A1.
Li Y, Wang SM, Li X, Lv CJ, Peng LY, Yu XF, Song YJ, Wang CJ. Li Y, et al. Pharm Biol. 2022 Dec;60(1):394-403. doi: 10.1080/13880209.2022.2034893. Pharm Biol. 2022. PMID: 35271397 Free PMC article.
CONTEXT: Pterostilbene (PTE), a common polyphenol compound, exerts an anti-inflammatory effect in many diseases, including acute lung injury (ALI). OBJECTIVE: This study explores the potential mechanism of PTE pre-treatment against lipopolysaccharide (LPS)-induced A …
CONTEXT: Pterostilbene (PTE), a common polyphenol compound, exerts an anti-inflammatory effect in many diseases, including acute l …
Overexpression of NR4A1 is associated with tumor recurrence and poor survival in non-small-cell lung carcinoma.
Zhu B, Yang JR, Jia Y, Zhang P, Shen L, Li XL, Li J, Wang B. Zhu B, et al. Oncotarget. 2017 Dec 8;8(69):113977-113986. doi: 10.18632/oncotarget.23048. eCollection 2017 Dec 26. Oncotarget. 2017. PMID: 29371962 Free PMC article. Retracted.
The expression level and clinical significance of NR4A1 are presently unknown in the non-small-cell lung carcinoma (NSCLC). ...The NR4A1 expression in NSCLC tumors and the adjacent matched para-carcinoma specimens were examined, and the association between …
The expression level and clinical significance of NR4A1 are presently unknown in the non-small-cell lung carcinoma (NSCLC). .. …
55 results